Tricyclic antidepressants for preventing migraine in adults

Tricyclic antidepressants for preventing migraine in adults

BACKGROUND Migraine, ranked as the 7th-highest specific cause of disability worldwide, has caused an enormous burden on the economy and society. Tricyclic antidepressant (TCA) is one of the most commonly drugs for migraine prevention. However, evidence about the efficacy and tolerability of TCAs in the prophylaxis of migraine in adults is somewhat confusing. METHODS A computerized literature ...

Tricyclic antidepressants for migraine and tension-type headaches

Tricyclic antidepressants have a long history in the treatment of headache. In 1964 Lance and Curran reported a better response to amitriptyline (30-75 mg/day) in chronic tension headache (n=280) compared with 11 other commonly used drugs (such as benzodiazepines, vasodilators, and sedatives). They also reported a placebo controlled crossover trial of 27 patients that showed clinically signific...

Tricyclic antidepressants.

Tricyclic antidepressants.

Correspondence BRiTISH 301 Tricyclic Antidepressants SIR,-I am worried by one sentence in the article on tricyclic antidepressants (13 April, p. 102): "Jaundice, which is very uncommon , is of the cholestatic type similar to that found in chlorpromazine." This is misleading. Jaundice is one of the more frequent side-effects reported from imipramine and imitrip-tyline, the most widely used membe...

Pharmacokinetics of Tricyclic Antidepressants

This review, together with Part 1 (Gun. Chem. 26: 5-17, 1980), summarizes progress in measurement of tricyclic antidepressants in biological fluids and the application of the methodology to Clinical practice. For many of the older drugs and for all of the new-generation antidepressants, further studies are required to delineate the precise relationship between plasma concentration and clinical ...